Screening anticancer activity by Brine shrimp lethality test of extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch) and Synadenium glaucescens (Pax)

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dc.contributor.authorRoberto Luis Nhamussua
dc.contributor.authorFaith Philemone Mabiki
dc.contributor.authorAlinanuswe Joel Mwakalesi
dc.contributor.authorLyndy Joy McGaw
dc.date.accessioned2026-07-06T14:09:22Z
dc.date.available2026-07-06T14:09:22Z
dc.date.issued2026-01
dc.descriptionJournal Article
dc.description.abstractCancer continues to be one of the main public health challenges, driving the search for new compounds with therapeutic potential. Medicinal plants represent a valuable promising source of bioactive metabolites, and the Brine Shrimp Lethality Test has been widely used as a preliminary tool to assess the toxicity of natural extracts, pro- viding clues to their possible anticancer activity. In this study, the cytotoxicity of the extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch), and Synadenium glaucescens (Pax) was investigated using the BSLT as a first step in screening for potential anticancer compounds. The plant materials were harvested in Tanzania and air-dried in the shade, and ground. The extracts were prepared by total sequential solvent extraction using cold maceration, starting with ethyl ace- tate, followed by methanol.
dc.identifier.citationNhamussua RL, Mabiki FP, Mwakalesi AJ, McGaw LJ (2026) Screening anticancer activity by Brine shrimp lethality test of extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch) and Synadenium glaucescens (Pax). PLoS One 21(1): e0336636. https://doi.org/10.1371/ journal.pone.0336636
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/20.500.14820/7678
dc.language.isoen
dc.publisherPLOS One
dc.subjectscreening
dc.subjectanticancer
dc.subjectcancer
dc.subjecttherapeutic potential
dc.subjectmedicinal plants
dc.subjectBrine Shrimp Lethality Test
dc.titleScreening anticancer activity by Brine shrimp lethality test of extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch) and Synadenium glaucescens (Pax)
dc.typeArticle

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