Screening anticancer activity by Brine shrimp lethality test of extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch) and Synadenium glaucescens (Pax)
Loading...
Date
2026-01
Journal Title
Journal ISSN
Volume Title
Publisher
PLOS One
Abstract
Cancer continues to be one of the main public health challenges, driving the search
for new compounds with therapeutic potential. Medicinal plants represent a valuable
promising source of bioactive metabolites, and the Brine Shrimp Lethality Test has
been widely used as a preliminary tool to assess the toxicity of natural extracts, pro-
viding clues to their possible anticancer activity. In this study, the cytotoxicity of the
extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch),
and Synadenium glaucescens (Pax) was investigated using the BSLT as a first step
in screening for potential anticancer compounds. The plant materials were harvested
in Tanzania and air-dried in the shade, and ground. The extracts were prepared by
total sequential solvent extraction using cold maceration, starting with ethyl ace-
tate, followed by methanol.
Description
Journal Article
Keywords
screening, anticancer, cancer, therapeutic potential, medicinal plants, Brine Shrimp Lethality Test
Citation
Nhamussua RL, Mabiki FP, Mwakalesi AJ, McGaw LJ (2026) Screening anticancer activity by Brine shrimp lethality test of extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch) and Synadenium glaucescens (Pax). PLoS One 21(1): e0336636. https://doi.org/10.1371/ journal.pone.0336636