Incidence and management practices of bacterial meningitis in children in Morogoro regional referral hospital
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Date
2013
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Publisher
Sokoine University of Agriculture
Abstract
The analysis and evaluation of meningitis situation in Morogoro Region was done by
looking at the incidence and management practices of meningitis in children at the
Morogoro Regional Referral Hospital (MRRF) for a period of 7 months. A total of 1352
children aged between 7 days and 12 years were admitted at MRRH, of these 72 (5.3%)
had meningitis symptoms during the period. Lumbar puncture was done on the 72
children with meningitis symptoms to collect CSF for observation and laboratory
analysis. Of the examined CSF samples, 23 (31.9%) were positive for Streptococcus
pneumoniae, 6 (8.3%) for Haemophilus influenzae, 5 (6.9%) for Group B Streptococcus,
3 (4.2 %) for Echerichia coli and one (1.4%) was AFB positive on Ziehl-Neelsen (ZN)
stain. Thirty nine percent (n=72) of the samples showed no bacterial growth in the culture
media. Latex agglutination test was used to confirm the bacterial colonies. The incidence
of meningitis infection was 5.3% (n=1352) among the admitted patients. Intravenous
administration of Ceftriaxone at 80mg/kg body weight was given once a day for 10 days
to all the 72 children with symptoms of meningitis. Of the 72 treated children, 32 (44.4%)
responded well to the treatment of whom 19 (26.4%) fully recovered, while 13 (18.1%)
recovered but with neurological defects. Nevertheless, 39 (54.2%) of the treated children
did not respond to the therapy whereas 31 (43.1%) of them died while 8 (11.1%) were
referred to the Muhimbili National Referral Hospital. Only one case of Tuberculosis (TB)
Meningitis was recorded which responded well to TB medication of rifampicin, isoniazid
and pyrazinamide in a combination. This study has shown that Streptococcus pneumoniae
was the major bacteria associated with meningitis in children admitted at the MRRH.
Description
Master's Theses
Keywords
Incidence, management practices, bacterial meningitis- children, Morogoro regional referral hospital