Correlation between type of adaptive immune response against porcine circovirus type 2 and level of virus replication
| dc.contributor.author | Meerts, Peter | |
| dc.contributor.author | Gucht, Van S | |
| dc.contributor.author | Cox, Eric | |
| dc.contributor.author | Vandebosch, A | |
| dc.contributor.author | Nauwynck, H. J | |
| dc.date.accessioned | 2022-05-19T13:54:57Z | |
| dc.date.available | 2022-05-19T13:54:57Z | |
| dc.date.issued | 2005-06-01 | |
| dc.description.abstract | Porcine circovirus 2 (PCV2) replication is characterized by high variation among infected pigs. This study investigated the role of immunologic responses in causing this variation. Twelve gnotobiotic pigs were inoculated with PCV2. Four of these pigs were treated with cyclosporin A (CysA) to monitor the effect of the adaptive immunity on the development of the PCV2 infection. Through lymph node biopsies at 10, 15, and 21 days postinoculation (DPI), PCV2 replication in lymphoid tissues was monitored. The production of total PCV2-specific and PCV2-neutralizing antibodies was followed, together with interferon-γ (IFN-γ) mRNA expression levels in peripheral blood monocytes as a marker for cellular immunity. In general, the CysA-treated pigs showed the highest PCV2 titers, indicating that the adaptive immunity is necessary to restrain PCV2 replication. Three different PCV2 replication patterns were observed in … | en_US |
| dc.identifier.uri | https://www.suaire.sua.ac.tz/handle/123456789/4191 | |
| dc.language.iso | en | en_US |
| dc.publisher | Mary Ann Liebert, Inc. | en_US |
| dc.subject | Correlation | en_US |
| dc.subject | Level of virus replication | en_US |
| dc.subject | Porcine circovirus type 2 | en_US |
| dc.subject | Adaptive immune response | en_US |
| dc.title | Correlation between type of adaptive immune response against porcine circovirus type 2 and level of virus replication | en_US |
| dc.type | Article | en_US |
| dc.url | www.liebertpub.com | en_US |