Subspecific rodent taxa as the relevant host taxonomic level for mammarenavirus host specificity

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dc.contributor.authorCuypers, Laura N.
dc.contributor.authorGryseels, Sophie
dc.contributor.authorBaird, Stuart J.E.
dc.contributor.authorSabuni, Christopher A.
dc.contributor.authorKatakweba, Abdul S.
dc.contributor.authorvan den Burg, Sebastiaan R.M.
dc.contributor.authorBryja, Josef
dc.contributor.authorLeirs, Herwig
dc.contributor.authorde Bellocq, Joëlle Goüy
dc.date.accessioned2026-08-14T08:19:08Z
dc.date.available2026-08-14T08:19:08Z
dc.date.issued2023
dc.descriptionArticle
dc.description.abstractMastomys natalensis-borne mammarenaviruses appear specific to subspecific M. natalensis taxa rather than to the whole species. Yet mammarenaviruses carried by M. natalensis are known to spill over and jump hosts in northern sub-Saharan Africa. Phylogeographic studies increasingly show that, like M. natalensis, small mammals in sub- Saharan Africa are often genetically structured into several subspecific taxa. Other mammarenaviruses may thus also form virus-subspecific host taxon associations. To investigate this, and if mammarenaviruses carried by M. natalensis in southern Africa are less prone to spill-over, we screened 1225 non-M. natalensis samples from Tanzania where many small mammal taxa meet. We found mammarenavirus RNA in 6 samples. Genetic/genomic characterisation confirmed they were not spill-over from M. natalensis. We detected host jumps among rodent tribe members and an association between mammarenaviruses and subspecific taxa of Mus minutoides and Grammomys surdaster, indicating host genetic structure may be crucial to understand virus distribution and host specificity.
dc.identifier.citationCorresponding author. E-mail address: lauracuypers@outlook.be (L.N. Cuypers). https://doi.org/10.1016/j.virol.2023.02.014
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/20.500.14820/7905
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofseriesVirology 581 (2023) 116–127
dc.subjectHost specificity
dc.subjectHost genetic structure
dc.subjectComparative phylogeography
dc.subjectSongea virus
dc.subjectBerega virus
dc.subjectNgerengere virus
dc.subjectMus minutoides
dc.subjectGrammomys surdaster
dc.subjectSpill-over
dc.subjectHost jump
dc.titleSubspecific rodent taxa as the relevant host taxonomic level for mammarenavirus host specificity
dc.typeArticle

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