Porcine cysticercosis in Angonia district, North-Western Mozambique: epidemiology and evaluation of the effectiveness and efficiency of oxfendazole treatment
| dc.contributor.author | Junior, Alberto Pondja | |
| dc.date.accessioned | 2023-09-04T05:45:36Z | |
| dc.date.available | 2023-09-04T05:45:36Z | |
| dc.date.issued | 2010 | |
| dc.description | Thesis | en_US |
| dc.description.abstract | A research was conducted to investigate the epidemiology of porcine cysticercosis in Angonia district, Mozambique, and to evaluate the effectiveness and efficiency of oxfendazole (OFZ) for the treatment of porcine cysticercosis. Prevalence and risk factors associated with porcine cysticercosis were determined in a cross-sectional survey conducted in 11 randomly selected villages. Out of 661 pigs screened, porcine cysticercosis was diagnosed in 12.7% and 34.9% by lingual examination and Ag-ELISA, respectively. Increasing age (OR = 1.63; 95% CI: 1.13, 2.37) and free-range pig husbandry system (OR = 3.81; 95% CI: 2.08, 7.06) were significant risk factors associated with the disease. The incidence of porcine cysticercosis was determined in a study conducted in 4 endemic villages. A total of 108 piglets were tested repeatedly for porcine cysticercosis (by Ag-ELISA) at 4, 9 and 12 months of age. The incidence rate of porcine cysticercosis increased significantly from 3.8 cases per 100 pig-months in the first period (between 4 and 9 months of age) to 19.3 cases per 100 pig-months in the second period (between 9 and 12 months of age). The effectiveness and efficiency of 30mg/kg dose of OFZ for the treatment of porcine cysticercosis were evaluated in a randomized control trial that involved 216 piglets. Fifty four piglets were treated at 4 months of age (OFZ-T1), other 54 piglets treated at 9 months (OFZ-T2) and matched with 108 controls. Baseline prevalence (by Ag-ELISA) was similar among the study groups. At 12 months of age, infections were found in 66.7% controls, 21.4% OFZ-T1 and 9.1% of the OFZ-T2 pigs. There was a significant risk reduction for cysticercosis if pigs were treated either at 4 months (OR = 0.14; 95% CI: 0.06, 0.34) or 9 months of age (OR = 0.05; 95% CI: 0.01, 0.15). Treating pigs with OFZ resulted in positive incremental net benefits. Porcine cysticercosis is endemic in Angonia district. Oxfendazole treatment is cost-effective, and combined with health education programs would have a significant contribution to the control of Taenia solium transmission. Further studies are needed to fine-tune the use of OFZ into a more practical field control tool for porcine cysticercosis. | en_US |
| dc.description.sponsorship | Danish International Development Agency (DANIDA) | en_US |
| dc.identifier.uri | http://www.suaire.sua.ac.tz/handle/123456789/5695 | |
| dc.language.iso | en | en_US |
| dc.publisher | Sokoine University of Agriculture | en_US |
| dc.subject | Porcine cysticercosis | en_US |
| dc.subject | Angonia district | en_US |
| dc.subject | North-Western Mozambique | en_US |
| dc.subject | Oxfendazole treatment | en_US |
| dc.title | Porcine cysticercosis in Angonia district, North-Western Mozambique: epidemiology and evaluation of the effectiveness and efficiency of oxfendazole treatment | en_US |
| dc.type | Thesis | en_US |