Crossing the Line: Seroprevalence and Risk Factors for Transboundary Animal Diseases Along the Tanzania-Zambia Border
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Date
2022-03-11
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers in Veterinary Science
Abstract
Transboundary pathogens pose a threat to livelihood security in countries such as
Zambia and Tanzania. This study aimed to investigate the seroprevalence of peste
des petits ruminants virus (PPRV), foot and mouth disease virus (FMDV), sheep and
goat pox virus (SGPV), Rift Valley fever virus (RVFV) and Brucella spp. in sheep and
goats along the Tanzania-Zambia border. Another aim was to assess the association
between certain predictor variables and seroprevalence, focusing on trade and proximity
to an international border, to a town and to the Tanzania-Zambia highway. During
September-October 2018, 486 serum samples from small ruminants in Zambia and 491
in Tanzania were collected and analyzed using enzyme-linked immunosorbent assays
(ELISA). A questionnaire focused on management strategies was administered to each
household. The animal-level seroprevalence in Zambia was 0.21% [95% confidence
interval (CI) (0.01–1.14) for PPRV, 1.03% (95% CI 0.33–2.39) for FMDV, 0% (95% CI
0–0.76) for SGPV, 2.26%(95%CI 1.14–4.01) for RVFV and 1.65%(95%CI 0.71–3.22) for
Brucella spp.]. In Tanzania, animal-level seroprevalence was 2.85% (95% CI 1.57–4.74)
for PPRV, 16.9% (95% CI 13.7–20.5) for FMDV, 0.20% (95% CI 0.01–1.13) for SGPV,
3.26%(95%CI 1.87–5.24) for RVFV and 20.0%(95%CI 14.5–26.5) for Brucella spp. For
PPRV (OR 6.83, 95% CI 1.37–34.0, p = 0.019) and FMDV (OR 5.68, 95% CI 1.58–20.3,
p = 0.008), herds situated more than 30 km from an international border were more
likely to be seropositive, while being located 10–30 km (OR 4.43, 95% CI 1.22–16.1
p = 0.024) from a border was identified as a risk factor for Brucella spp. For FMDV (OR
79.2, 95% CI 4.52–1388.9, p = 0.003), being situated within 30 km from a town was
associated with seropositivity.Furthermore, contact with wild ruminants (OR 18.2, 95%
CI 1.36–244), and the presence of sheep in the household (OR 5.20, 95% CI 1.00–26.9,
p = 0.049), was associated with seropositivity for PPRV, and FMDV. No significantassociations between trade or distance to the Tan-Zam highway and seroprevalence
were found. We recommend that the impact of trade and proximity to borders, towns
and roads should be further evaluated in larger studies, ideally incorporating aspects
such as temporal trade fluctuations.
Description
Keywords
Rift Valley fever, peste des petits ruminants,, Brucellosis, Foot and mouth disease, Sheep and goat pox, Seroprevalence, Risk factors
Citation
Lysholm S, Lindahl JF, Munyeme M, Misinzo G, Mathew C, Alvåsen K, Dautu G, Linde S, Mitternacht L, Olovsson E, Wilén E, Berg M and Wensman JJ (2022) Crossing the Line: Seroprevalence and Risk Factors for Transboundary Animal Diseases Along the Tanzania-Zambia Border. Front. Vet. Sci. 9:809128. doi: 10.3389/fvets.2022.809128