Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from synadenium glaucescens pax
Loading...
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
The Journal of Phytopharmacology
Abstract
The use of plants as sources of drug agents is attributed by factors among which are the easy
accessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditional
medicine and drug discovery field necessitates investigation of pure compounds in any plant with
medicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plant
in Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis of
ethanolic and methanolic extracts of root and stem barks respectively aided to isolated six pure
compounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while their
spectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was a
phenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and euphol-
SG5), one steroid (β-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicity
evaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practically
non-toxic.
Description
Journal Article
Keywords
Triterpene, Lupeol, Friedelanol, NMR, Euphorbiaceae, Brine shrimp