Prevalence and risk factors associated with tuberculosis and drug resistance-tuberculosis among illicit drug users in Temeke, Dar es Salaam, Tanzania
| dc.contributor.author | Said, Aziza Ahmed | |
| dc.date.accessioned | 2022-09-29T09:01:30Z | |
| dc.date.available | 2022-09-29T09:01:30Z | |
| dc.date.issued | 2021 | |
| dc.description | Dissertation | en_US |
| dc.description.abstract | Tuberculosis (TB) is among ancient diseases which for over 4000 years has been affecting mankind. Tanzania is among the 22 TB high burden countries despite government’s efforts to fight the disease. Illicit drug users (IDU) constitute the population at high risk of harboring TB infection in the community. A cross sectional study was conducted between April and August 2020 to investigate the prevalence and risk factors associated with TB and drug-resistant TB amongst illicit drug users in Temeke district, Dar es Salaam. A total of 384 IDUs were recruited, each consenting participant providing spot sputum sample which was analyzed using GeneXpert, smear microscopy and LJ culture at Central TB reference laboratory (CTRL) in Dar es Salaam. Information on IDUs was obtained through structured Questionnaires and analyzed using univariate analysis in General Linear Model, variables with p-value < 0.2 were further analyzed using Binary Logistic Regression using IBM SPSS Version 20, variables with p-values < 0.05 were considered statistically significant. Overall, TB prevalence among IDUs was 9.89% which was significantly high compared to the reported TB prevalence of 0.25% in Tanzanian general population in 2018. Prevalence of TB among active IDUs was 16.15% and IDUs under methadone was 3.6%. Prevalence of Drug Resistance TB was found to be 2.43% for overall IDUs, among active IDUs was 3.23% and 0% for IDUs under methadone treatment. Previous TB treatment interference, HIV positivity and active illicit drug use were the risk factors significantly associated with TB infection, with (p=0.001, OR=140. 6, 95% CI=17.4-1129.9), (p=0.024; OR=2.2, 95% CI=1.4-3.3) and (p=0.004, OR=5.1, 95% CI=2.2-11.9) respectively. These findings call for immediate intervention strategies specifically focusing amongst population at high risk of acquiring and spreading TB, through ensuring early diagnosis and proper treatment to avoid long transmission time of the disease in communities. | en_US |
| dc.description.sponsorship | Southern African Centre in Infectious Diseases Survaillance African Centre of Excellence (SACIDS-ACE) | en_US |
| dc.identifier.uri | http://www.suaire.sua.ac.tz/handle/123456789/4614 | |
| dc.language.iso | en | en_US |
| dc.publisher | Sokoine University of Agriculture | en_US |
| dc.subject | Tuberculosis risk factors | en_US |
| dc.subject | Drug resistance | en_US |
| dc.subject | Drug users | en_US |
| dc.subject | Harboring TB infection | en_US |
| dc.subject | Tanzania | en_US |
| dc.subject | Temeke municipality | en_US |
| dc.title | Prevalence and risk factors associated with tuberculosis and drug resistance-tuberculosis among illicit drug users in Temeke, Dar es Salaam, Tanzania | en_US |
| dc.type | Thesis | en_US |