Effect of crude root extract from synadenium glaucescens on selected bacterial infections in albino mice (mus musculus)

Simple item page
dc.contributor.authorMwageni, Christer
dc.date.accessioned2026-04-18T15:58:18Z
dc.date.available2026-04-18T15:58:18Z
dc.date.issued2011
dc.descriptionMasters Theses
dc.description.abstractThe plant. Synadeniuni glaucescens. is widely used in Tanzania to treat various diseases including skin conditions, sores and wounds. However, systematic information about the effectiveness of traditionally prepared S. glaucescens extracts against microbial agents is scanty. In vivo studies using mice were carried out to investigate the effect of root extract from the plant against two pathogenic species of bacteria. A total of 120 mice were used in two experiments involving two bacterial species, Staphylococcus aureus and Pseudomonas aeruginosa. In each experiment, 60 mice were randomly divided into 6 groups with or without bacterial infection and with or without root extract. Clinical signs and survival rate were monitored and skin, kidneys and livers were examined for gross lesions, histopathological changes and bacterial counts. Results indicated that mice infected with the two bacteria and treated with the root extract from S. glaucescens had significantly less (P < 0.05) severe skin lesions compared to untreated control groups. Histopathological study of liver and kidney tissues showed hydropic degeneration and inflammatory reaction in uninfected groups receiving the extracts. Protein in tubular lumens, desquamated tubular epithelium and necrosis around central veins were observed in livers of mice infected with 5. aureus following infection and treatment with the extract. It is concluded that root extract from S. glaucescens had significant bacterial activity against the two tested bacteria. Histopathological changes in the kidneys and livers of mice which received the extract alone suggest that high doses of prolonged exposure of the tested extract could be harmful to the mice. Further studies are needed to find out optimum dosage and whether the extract is harmful to other organs.
dc.description.sponsorshipThe Belgium Technical Cooperation (BTC)
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/20.500.14820/7486
dc.language.isoen
dc.publisherSokoine University of Agriculture
dc.subjectMedicinal plants
dc.subjectBacterial infections-albino mice
dc.subjectMus musculus
dc.subjectCrude root extract
dc.titleEffect of crude root extract from synadenium glaucescens on selected bacterial infections in albino mice (mus musculus)
dc.typeThesis

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Crister_Mwageni_SUA_MSC_2011.pdf
Size:
2.92 MB
Format:
Adobe Portable Document Format
Description:
Master of Science in Applied Microbiology
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Theses and Dissertations Collection