Tuberculosis detection by pouched rats: Opportunities for reinforcement under low-prevalence conditions
| dc.contributor.author | Edwards, T. L. | |
| dc.contributor.author | Ellis, H. | |
| dc.contributor.author | Watkins, E. E. | |
| dc.contributor.author | Mulder, C. | |
| dc.contributor.author | Mgode, G. | |
| dc.contributor.author | Cox, C. | |
| dc.contributor.author | Poling, A. | |
| dc.date.accessioned | 2020-06-19T11:31:30Z | |
| dc.date.available | 2020-06-19T11:31:30Z | |
| dc.date.issued | 2017 | |
| dc.description | Article in Press of Behavioural Processes 2017 | en_US |
| dc.description.abstract | Giant African pouched rats (Cricetomys ansorgei) have been employed successfully in two operational tuberculosis-detection projects in which they sniff sputum samples from symptomatic individuals who have visited tuberculosis clinics. The prevalence of pulmonary tuberculosis in this population is high, approximately 20% in the regions where the rats have been used. If the rats are to be used to screen individuals from lower- prevalence populations, their performance under such conditions must first be evaluated. In this study, the prevalence of tuberculosis-positive samples presented to eight pouched rats was reduced to approximately 5%, and the percentage of known-positive samples included as opportunities for reinforcement was varied in sequence from 10 to 8, 6, 4, 2, 4, and 2. Liquid food reinforcers were delivered for identification responses to known-positive samples and at no other time. The rats’ accuracy was clinically and statistically significantly lower at 2% than at the other values. These results indicate that the rats can perform well in low-prevalence scenarios but, if they are used under the conditions of the present study, at least 4% of the samples presented to them must be opportunities for reinforcement. | en_US |
| dc.identifier.uri | https://www.suaire.sua.ac.tz/handle/123456789/3092 | |
| dc.language.iso | en | en_US |
| dc.publisher | 2017 Elsevier B.V | en_US |
| dc.subject | Concept formation | en_US |
| dc.subject | Cricetomys ansorgei | en_US |
| dc.subject | Discrimination learning | en_US |
| dc.subject | Pulmonary tuberculosis | en_US |
| dc.subject | Scent detection | en_US |
| dc.subject | Techniques-procedures Diagnostic | en_US |
| dc.title | Tuberculosis detection by pouched rats: Opportunities for reinforcement under low-prevalence conditions | en_US |
| dc.type | Article | en_US |
| dc.url | http://dx.doi.org/10.1016/j.beproc.2017.05.015, www.elsevier.com/locate/behavproc | en_US |