Rapid molecular evolution of pain insensitivity in multiple African rodents

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dc.contributor.authorEigenbrod, O.
dc.contributor.authorDebus, K. Y.
dc.contributor.authorReznick, J.
dc.contributor.authorBennett, N. C.
dc.contributor.authorSánchez-Carranza, O.
dc.contributor.authorOmerbašić, D.
dc.contributor.authorHart, D. W.
dc.contributor.authorBarker, A. J.
dc.contributor.authorZhong, W.
dc.contributor.authorLutermann, H.
dc.contributor.authorKatandukila, J. V.
dc.contributor.authorMgode, G.
dc.contributor.authorPark, T. J.
dc.contributor.authorLewin, G. R.
dc.date.accessioned2020-06-08T15:10:21Z
dc.date.available2020-06-08T15:10:21Z
dc.date.issued2019-05-31
dc.descriptionResearch Article of Science 364, pg. 852–859 (2019)en_US
dc.description.abstractNoxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Na v 1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors. These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant. Our study reveals how evolution can be used as a discovery tool to find molecular mechanisms that shut down pain.en_US
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/3081
dc.language.isoenen_US
dc.publisherScience sciencemagen_US
dc.subjectRapid molecular evolutionen_US
dc.subjectPain insensitivityen_US
dc.subjectMultiple African rodentsen_US
dc.titleRapid molecular evolution of pain insensitivity in multiple African rodentsen_US
dc.typeArticleen_US
dc.urlhttps://science.sciencemag.org/content/364/6443/852en_US

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