Isolation and cytotoxicity evaluation of long chain bioactive compounds from commiphora swynnertonii (Burtt)
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Scientific and Innovative Research
Abstract
Commiphora swynnertonii (Burtt) is a medicinal plant with diverse traditional uses in Tanzania. However, there
is limited information on isolation and cytotoxicity properties of bioactive compounds responsible for its
pharmacological activities. Hence, this study attempted to isolate and assess toxicity properties of bioactive
compounds from its leaves, stem barks and whole root. Isolation of bioactive compounds was done by column
chromatography method. There structures were deduced with the aid of NMR and GC-MS data and comparison
with spectral data available in the literatures. Cytotoxicity evaluation was done by brine shrimp lethality test
(BSLT) method. Chromatographic separation led to isolation of Hexacosane (1), Ethyl octadecanoate (2) and
Octacosanol (3) from the leaves; Ethyl pentadecanoate (4) and Hexacosanoic acid (5) from the stem barks and
Ethyl tetradecanoate (6), Methyl pentadecanoate (7) and Ethyl hexadecanoate (8) from the whole root. BSLT
evaluation revealed that all compounds were non-toxic to brine shrimp larvae (LC 50 >100 μg/ml).
This study reports the isolation of these compounds for the first time from this plant, moreover, their presence
demonstrates the usefulness of C. swynnertonii as a good source of pharmacological active reported compounds
which authenticate its diverse uses in traditional medicine. Furthermore, the revealed non-toxic effect of these
compounds shows safety and possibly its traditional use has no cytotoxicity effect. Yet, further studies on toxicity
of these compounds are recommended.
Description
Journal Article
Keywords
Bioactive Compounds, Brine Shrimp Test, Burseraceae, Commiphora swynnertonii, Long- Chain Compounds, Toxicity