Relation between alpha+-thalassemia and glutathione-s-transferases polymorphisms in children with severe malaria in Tanzania
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Date
2011
Authors
Journal Title
Journal ISSN
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Publisher
Sokoine University of Agriculture
Abstract
Malaria remains a major public health problem in Sub-Saharan Africa. In Tanzania.
malaria is believed to cause about 30% annual episodes and 15% death compared to
other diseases. Alpha’-thalasscmia and common glutathione-S-transferase (GST)
genotypic polymorphisms have been reported independently to confer protection
against severe malaria, but the molecular basis for their individual protection is
largely unknown. The relationship between genotypic polymorphisms of alpha*-
thalassemia and GST in children with severe malaria was determined in a cross
sectional-retrospective study using 148 children aged between 1 and 15 years. The
study was conducted at Mnyuzi village in Korogwe district. Northeastern of
Tanzania. Glulalhione-S-transferase-pil (GSTP\ ^polymorphism was observed to
have almost three fold risk (OR = 2.9; 95% CI =1.3- 6.1; P = 0.006) of developing
severe malaria in children compared to mild malaria. In the presence of GSTP\,
decrease in protective effect of alpha*-thalassemia polymorphisms (homozygotes and
heterozygotes) against severe malaria was observed from OR = 0.81 (95% CI = 0.5-
1.5; P = 0.5) to OR = 0.78 (95% CI = 0.4-1.5; P = 0.44). This study concludes that
GSTP\ polymorphism increases malaria severity. Also there is slight inverse
relationship between GSTP\ polymorphisms and alpha'-thalassemia to children with
severe malaria.
Description
Master's Theses
Keywords
Alpha+-thalassemia- children-severe malaria, Thalassemia, Glutathione-s-transferases polymorphisms, children-severe malaria, Tanzania