Comparison of analgesia and cardio-pulmonary effects of epidural injection of pethidine and lidocaine in small East African goats
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Date
2013
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
RESEARCH OPINIONS IN ANIMAL & VETERINARY SCIENCES (ROAVS)
Abstract
Analgesic and cardiopulmonary effects of epidural injections of 2% lidocaine (4mg/kg, n=6) and pethidine
(2.5mg/kg, n=6) were compared in healthy goats weighing 18-25 kg. All drugs were injected at lumbosacral
epidural space. Mean heart rate, respiration rate, rectal temperature, analgesia effect (response to pinprick stimuli),
sedation and motor incoordination were determined. Results were recorded before and at various times (every 5
minutes for the first 10 minutes and every 10 minutes upto 2 hrs) after the epidural injection. Onset of analgesia was
after 5 minutes following injection of either lidocaine or pethidine. Duration of analgesia was over 120 minutes and
60 minutes after epidural injection of lidocaine and pethidine respectively. Hind limb paralysis was observed in
goats that received lidocaine while only mild incoordination was observed in pethidine treated goats except for one
goat that remained recumbent for the entire observation period. Significant increase in body temperature was
recorded in 10 minutes after pethidine injection but did not change following lidocaine injection. There was no
significant change in heart rate following epidural injection of lidocaine but significantly decreased following
pethidine injection. Respiration rate significantly increased in lidocaine group but did not change in pethidine treated
goats. Results of this study indicate that epidural injection of pethidine at a dose of 2.5 mg/kg produce analgesia of a
shorter duration compared to lidocaine, but is sufficient and safe for short duration surgeries of the perineal region in
goats.
Description
Res. Opin. Anim. Vet. Sci., 2013, 3(2), pp, 30-34.
Keywords
Spinal analgesia, Opiatesn, Caprine, Pai