Susceptibility of campylobacter strains to selected natural products and frontline antibiotics

Simple item page
dc.contributor.authorGahamanyi, Noel
dc.contributor.authorSong, Dae-Geun
dc.contributor.authorHyun Cha, Kwang
dc.contributor.authorYoon, Kye-Yoon
dc.contributor.authorLeonard E.
dc.contributor.authorMboera, G.
dc.contributor.authorMatee, Mecky I.
dc.contributor.authorMutangana, Dieudonné
dc.contributor.authorAmachawadi, Raghavendra G.
dc.contributor.authorKomba, Erick V. G.
dc.contributor.authorPan, Cheol-Ho
dc.date.accessioned2025-12-24T08:06:58Z
dc.date.available2025-12-24T08:06:58Z
dc.date.issued2020
dc.descriptionJournal article
dc.description.abstractCampylobacter species have developed resistance to existing antibiotics. The development of alternative therapies is, therefore, a necessity. This study evaluates the susceptibility of Campylobacter strains to selected natural products (NPs) and frontline antibiotics. Two C. jejuni strains (ATCC® 33560TM and MT947450) and two C. coli strains (ATCC® 33559TM and MT947451) were used. The antimicrobial potential of the NPs, including plant extracts, essential oils, and pure phytochemicals, was evaluated by broth microdilution. The growth was measured by spectrophotometry and iodonitrotetrazolium chloride. Antibiotic resistance genes (tet(O) and gyrA) were characterized at the molecular level. The minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) ranged from 25 to 1600 μg/mL. Cinnamon oil, (E)-Cinnamaldehyde, clove oil, eugenol, and baicalein had the lowest MIC and MBC values (25–100 μg/mL). MT947450 and MT947451 were sensitive to erythromycin and gentamicin but resistant to quinolones and tetracycline. Mutations in gyrA and tet(O) genes from resistant strains were confirmed by sequencing. The findings show that NPs are effective against drug-sensitive and drug-resistant Campylobacter strains. The resistance to antibiotics was confirmed at phenotypic and genotypic levels. This merits further studies to decipher the action mechanisms and synergistic activities of NPs
dc.description.sponsorshipMinistry of Oceans and Fisheries, Korea (grant number 20170488), and the Partnership for Skills in Applied Sciences, Engineering, and Technology—Regional Scholarship and Innovation Fund (PASET-RSIF) in collaboration with the Government of the Republic of Korea.
dc.identifier.citationdoi:10.3390/antibiotics9110790
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/20.500.14820/7202
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofseriesAntibiotics 2020, 9, 0790
dc.subjectAntibiotics
dc.subjectCampylobacter
dc.subjectPlant extracts
dc.subjectEssential oils
dc.subjectPhytochemicals
dc.subjectResistance
dc.titleSusceptibility of campylobacter strains to selected natural products and frontline antibiotics
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
antibiotics-09-00790-v2.pdf
Size:
852.56 KB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Articles, Conference and Workshop Papers Collection