Sokoine University of Agriculture

In ovo antiviral activity of Synadenium glaucescens (pax) crude extracts on Newcastle disease virus

Show simple item record Mabiki, F.P Mdegela, R. H. Mosha, R.D Magadula, J.J 2017-03-23T08:45:21Z 2017-03-23T08:45:21Z 2013-04-10
dc.identifier.issn 1996-0875
dc.description Journal of Medicinal Plants Research 2013, 7(14): 863-870. en_US
dc.description.abstract Investigation on the effect of root bark and wood, stem bark and wood, leaves and sap of Synadenium glaucescens extracts against Newcastle disease (ND) virus was done using an in ovo assay. Viable 9 days embryonated chicken eggs were arranged into 25 treatment groups (n = 5). Groups 1 to 21 were challenged with a 13C/SUA virulent strain of ND virus treated with extract at concentration of 0.2 mg/ml. Un-inoculated group saved as negative control and groups inoculated with virus and diluent saved as positive controls. Haemagglutination test was used to quantify the amount for ND virus units. Embryo survival and embryo weight were significantly higher (P ≤ 0.05) in groups treated with S. glaucescens extracts than the positive control. The root bark demonstrated significantly higher antiviral activities (P ≤ 0.05). Furthermore, treatments with ethanolic extract SE1 resulted into 100% embryo survival, 91.2% mean embryo weight and reduced viral load by 99.2%. The minimum dose of SE1 with the highest efficacy was 0.2 mg/ml. The percent mean embryo weight and haemagglutination test demonstrated negative correlation (R2 = 0.94). These findings validate the ethnoveterinary potential of S. glaucescens and the feasibility of its use for treatment and control of ND. en_US
dc.language.iso en en_US
dc.subject Ethnoveterinary en_US
dc.subject Euphorbiaceae en_US
dc.subject Poultry viral diseases en_US
dc.subject Newcastle disease en_US
dc.title In ovo antiviral activity of Synadenium glaucescens (pax) crude extracts on Newcastle disease virus en_US
dc.type Article en_US

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