Antibody response, viral load, viral clearance and growth rate in Tanzanian free-range local chickens infected with lentogenic Newcastle disease virus

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dc.contributor.authorGallardo, Rodrigo
dc.contributor.authorKelly, Terra
dc.contributor.authorLamont, Susan
dc.contributor.authorDekkers, Jack
dc.contributor.authorZhou, Huaijun
dc.contributor.authorMuhairwa, Amandus
dc.contributor.authorMushi, James Richard
dc.contributor.authorChiwanga, Gaspar Honorati
dc.contributor.authorMollel, Esther Lemburis
dc.contributor.authorWalugembe, Muhammed
dc.contributor.authorMax, Robert Arsen
dc.contributor.authorMsoffe, Peter Makenga
dc.contributor.authorRodrigo Gallardo
dc.date.accessioned2022-05-11T06:24:39Z
dc.date.available2022-05-11T06:24:39Z
dc.date.issued2021-04-15
dc.description.abstractThis study is aimed at evaluating antibody responses, viral loads, viral clearance and growth rate of Tanzanian free-range local chicken (FRLC) challenged with LaSota strain of Newcastle disease virus (NDV) as indicator traits for selection of chickens for breeding with enhanced resistance to the disease and economic value. Three popular free-range local chicken ecotypes: Kuchi, Ching’wekwe and Morogoro-medium from three ecological zones of Tanzania were used for the experiments. Progenies from the breeder chickens were challenged with 10 7 titer of 50% egg infectious dose (EID 50 ) of the virus at 28 days of age. The viral loads and viral clearance rates evaluated by qRT-PCR from tear samples collected at 2- and 6-days post infection (dpi) showed that Kuchi could clear NDV better than Morogoro- medium and Ching’wekwe. Anti-NDV antibody levels determined from blood samples collected at 10 dpi using ELISA showed that Kuchi ecotype expressed higher mean anti-NDV antibodies compared to Morogoro-medium and Ching’wekwe. Growth rates determined from body weights collected for 38 days from day of hatch (D0) to 10 dpi showed higher growth rate for Kuchi than Morogoro-medium and Ching’wekwe chickens. Kuchi chickens were potentially more resistant to ND compared to Morogoro- medium and Ching’wekwe.en_US
dc.identifier.issn2141-2529
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/4102
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectFree-range local chickensen_US
dc.subjectNewcastle diseaseen_US
dc.subjectImmune responseen_US
dc.subjectInnate resistanceen_US
dc.titleAntibody response, viral load, viral clearance and growth rate in Tanzanian free-range local chickens infected with lentogenic Newcastle disease virusen_US
dc.typeArticleen_US
dc.urlhttp://www.academicjournals.org/JVMAHen_US

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