Mwanyika, Gaspary O.Sindato, CalvinRugarabamu, SimaRumisha, Susan F.Karimuribo, Esron D.Misinzo, GeraldRweyemamu, Mark M.Hamid, Muzamil M. AbdelHaider, NajmulVairo, FrancescoKock, RichardMboera, Leonard E.G.2022-09-062022-09-062021http://www.suaire.sua.ac.tz/handle/123456789/4523International Journal of Infectious Diseases 111 (2021) pp. 271–280Background: This study was conducted to determine the seroprevalence and risk factors of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses in Tanzania. Methods: The study covered the districts of Buhigwe, Kalambo, Kilindi, Kinondoni, Kondoa, Kyela, Mvomero, and Ukerewe in Tanzania. Blood samples were collected from individuals recruited from house- holds and healthcare facilities. An ELISA was used to screen for immunoglobulin G antibodies against CHIKV, DENV, and ZIKV. Results: A total of 1818 participants (median age 34 years) were recruited. The overall CHIKV, DENV, and ZIKV seroprevalence rates were 28.0%, 16.1%, and 6.8%, respectively. CHIKV prevalence was highest in Buhigwe (46.8%), DENV in Kinondoni (43.8%), and ZIKV in Ukerewe (10.6%) and Mvomero (10.6%). Increas- ing age and frequent mosquito bites were significantly associated with CHIKV and DENV seropositivity ( P < 0.05). Having piped water or the presence of stagnant water around the home ( P < 0.01) were as- sociated with higher odds of DENV seropositivity. Fever was significantly associated with increased odds of CHIKV seropositivity ( P < 0.001). Visiting mines had higher odds of ZIKV seropositivity ( P < 0.05). Conclusions: These findings indicate that DENV, CHIKV, and ZIKV are circulating in diverse ecological zones of Tanzania. There is a need to strengthen the control of mosquito-borne viral diseases in Tanzania.enChikungunyaDengue ZikaSeroprevalenceRisk factorsTanzaniaSeroprevalence and associated risk factors of chikungunya, dengue, and zika in eight districts in TanzaniaArticle