Sokoine University of Agriculture

Contribution of microbiota to the intestinal physicochemical barrier

Show simple item record Malago, J.J. 2018-10-09T05:19:03Z 2018-10-09T05:19:03Z 2015
dc.identifier.other doi: 10.3920/BM2014.0041.
dc.description Beneficial Microbes, 2015; 6(3): 295-311 en_US
dc.description.abstract The large number of intestinal microorganisms, which exceeds the total number of human cells by ten folds, alludes to a significant contribution to human health. This is vivid in enteric and some systemic diseases emanating from disruption of the microbiota. As life style keeps shifting towards disruption of the microbiota in most societies worldwide, interest in the contribution of the microbiota to gut health has grown enormously. Many studies have been conducted to elucidate the exact contribution of the microbiota to human health. The knowledge gained from these studies indicates that the microbiota interacts with the intestinal milieu to maintain gut health. In this review, the crosstalk of microbiota with the intestinal physicochemical barrier pivotal to the gut innate immunity is highlighted. In particular, the review focuses on the role of the microbiota on competitive exclusion of pathogens, intestinal pH, epithelial mechanical barrier integrity, apical actin cytoskeleton, antimicrobial peptides, and the mucus layer. Understanding this microbe-host relationship will provide useful insight into overcoming some diseases related to the disruption of the host microbiota. en_US
dc.language.iso en en_US
dc.publisher Beneficial Microbes en_US
dc.subject Antimicrobial peptides en_US
dc.subject Competitive exclusion en_US
dc.subject Low pH en_US
dc.subject Mucus layer en_US
dc.subject Tight junctions en_US
dc.title Contribution of microbiota to the intestinal physicochemical barrier en_US
dc.type Article en_US
dc.url en_US

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