Sokoine University of Agriculture

Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats

Show simple item record

dc.contributor.author Malago, J. J.
dc.contributor.author Sangu, C. L.
dc.date.accessioned 2018-06-14T12:35:29Z
dc.date.available 2018-06-14T12:35:29Z
dc.date.issued 2015
dc.identifier.issn 1673-1581
dc.identifier.uri https://www.suaire.sua.ac.tz/handle/123456789/2364
dc.description Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) en_US
dc.description.abstract Intrarectal infusion of butyrate improves colorectal disorders including ulcerative colitis (UC). However, it is not established whether systemically administered butyrate benefits such patients. The current study aimed at exploring and comparing the potential of intraperitoneally, intrarectally, and orally administered butyrate against acetic acid (AA)-induced UC in rats. Intrarectal administration of 2 ml of 50% AA was done after or without prior treatment of rats for 7 consecutive days with 100 mg/kg sodium butyrate (SB) intraperitoneally, intrarectally, or orally. Rats were sacrificed after 48 h of AA-treatment. Subsequently, colon sections were processed routinely for histopathological examination. We clinically observed diarrhea, loose stools, and hemoccult-positive stools, and histologically, epithelial loss and ulceration, crypt damage, goblet cell depletion, hemorrhage, and mucosal infiltration of inflammatory cells. The changes were significantly reduced by intraperitoneal, intrarectal, or oral butyrate, with intraperitoneal butyrate exhibiting the highest potency. It is concluded that intraperitoneal administration of butyrate abrogates the lesions of AA-induced UC and its potency surpasses that of intrarectal or oral butyrate. en_US
dc.language.iso en en_US
dc.publisher Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) en_US
dc.subject Butyrate en_US
dc.subject Oral administration en_US
dc.subject Intraperitoneal administration en_US
dc.subject Intrarectal administration en_US
dc.subject Acetic acid en_US
dc.subject Ulcerative colitis en_US
dc.title Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats en_US
dc.type Article en_US
dc.url www.zju.edu.cn/jzus; www.springerlink.com en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search SUA IR


Browse

My Account

Statistics