Sokoine University of Agriculture

Leptospira serovars for diagnosis of leptospirosis in humans and animals in Africa: common leptospira isolates and reservoir hosts

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dc.contributor.author Mgode, Georgies F.
dc.contributor.author Machang’u, Robert S.
dc.contributor.author Mhamphi, Ginethon G.
dc.contributor.author Katakweba, Abdul
dc.contributor.author Mulungu, Loth S.
dc.contributor.author Durnez, Lies
dc.contributor.author Leirs, Herwig
dc.contributor.author Hartskeerl, Rudy A.
dc.contributor.author Belmain, Steven R.
dc.date.accessioned 2016-12-02T11:49:20Z
dc.date.available 2016-12-02T11:49:20Z
dc.date.issued 2015
dc.identifier.uri https://www.suaire.sua.ac.tz/handle/123456789/1071
dc.description.abstract The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for inclusion in the antigen panel of the gold standard microscopic agglutination test (MAT) for detecting antibodies against leptospirosis. To gain insight in Leptospira serovars and their natural hosts occurring in Tanzania, concomitantly enabling the improvement of the MAT by inclusion of fresh local isolates, a total of 52 Leptospira isolates were obtained from fresh urine and kidney homogenates, collected between 1996 and 2006 from small mammals, cattle and pigs. Isolates were identified by serogrouping, cross agglutination absorption test (CAAT), and molecular typing. Common Leptospira serovars with their respective animal hosts were: Sokoine (cattle and rodents); Kenya (rodents and shrews); Mwogolo (rodents); Lora (rodents); Qunjian (rodent); serogroup Grippotyphosa (cattle); and an unknown serogroup from pigs. Inclusion of local serovars particularly serovar Sokoine in MAT revealed a 10-fold increase in leptospirosis prevalence in Tanzania from 1.9% to 16.9%in rodents and 0.26% to 10.75% in humans. This indicates that local serovars are useful for diagnosis of human and animal leptospirosis in Tanzania and other African countries. en_US
dc.language.iso en en_US
dc.subject Leptospira Serovars en_US
dc.subject Diagnosis en_US
dc.subject Leptospira Isolates en_US
dc.subject Grippotyphosa en_US
dc.title Leptospira serovars for diagnosis of leptospirosis in humans and animals in Africa: common leptospira isolates and reservoir hosts en_US
dc.type Article en_US


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