Sokoine University of Agriculture

A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle

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dc.contributor.author Lankester, F
dc.contributor.author Lugelo, A
dc.contributor.author Ndabigaye, A
dc.contributor.author Mnyambwa, N
dc.contributor.author Keyyu, J.
dc.contributor.author Kazwala, R.
dc.contributor.author Grant, D
dc.contributor.author Percival, A.
dc.contributor.author Deane, D
dc.contributor.author Haig, D.M.
dc.contributor.author Cleaveland, S.
dc.contributor.author Russell, G. C.
dc.date.accessioned 2017-12-11T05:59:22Z
dc.date.available 2017-12-11T05:59:22Z
dc.date.issued 2016
dc.identifier.uri http://www.suaire.suanet.ac.tz:8080/xmlui/handle/123456789/1863
dc.description.abstract Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seasons on the Simanjiro Plain of northern Tanzania. Each of the two phases of the field trial consisted of groups of 50 vaccinated and unvaccinated cattle, which were subsequently exposed to AlHV-1 challenge by herding toward wildebeest. Vaccination resulted in the induction of virus-specific and virus-neutralizing antibodies. Some cattle in the unvaccinated groups also developed virus-specific antibody responses but only after the start of the challenge phase of the trial. PCR of DNA from blood samples detected AlHV-1 infection in both groups of cattle but the frequency of infection was significantly lower in the vaccinated groups. Some infected animals showed clinical signs suggestive of MCF but few animals went on to develop fatal MCF, with similar numbers in vaccinated and unvaccinated groups. This study demonstrated a baseline level of MCF-seropositivity among cattle in northern Tanzania of 1% and showed that AlHV-1 virus-neutralizing antibodies could be induced in Tanzanian zebu shorthorn cross cattle by our attenuated vaccine, a correlate of protection in previous experimental trials. The vaccine reduced infection rates by 56% in cattle exposed to wildebeest but protection from fatal MCF could not be determined due to the low number of fatal cases. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Malignant catarrhal fever en_US
dc.subject Alcelaphine herpesvirus en_US
dc.subject Wildebeest en_US
dc.subject Vaccine field trial en_US
dc.subject Vaccine efficacy en_US
dc.subject Tanzania en_US
dc.title A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle en_US
dc.type Article en_US
dc.url http://www.sciencedirect.com/science/article/pii/S0264410X15017818 en_US


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