Arenavirus dynamics in experimentally and naturally infected rodents

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dc.contributor.authorMarien, Joachim
dc.contributor.authorBorremans, Benny
dc.contributor.authorGryseels, Sophie
dc.contributor.authorBroecke, Bram Vanden
dc.contributor.authorBecker-Ziaja, Beate
dc.contributor.authorMakundi, Rhodes
dc.contributor.authorMassawe, Apia
dc.contributor.authorReijniers, Jonas
dc.contributor.authorLeirs, Herwig
dc.date.accessioned2022-05-19T06:09:16Z
dc.date.available2022-05-19T06:09:16Z
dc.date.issued2017-06
dc.description.abstractInfectious diseases of wildlife are typically studied using data on antibody and pathogen levels. In order to interpret these data, it is necessary to know the course of antibodies and pathogen levels after infection. Such data are typically collected using experimental infection studies in which host individuals are inoculated in the laboratory and sampled over an extended period, but because laboratory conditions are controlled and much less variable than natural conditions, the immune response and pathogen dynamics may differ. Here, we compared Morogoro arenavirus infection patterns between naturally and experimentally infected multimammate mice (Mastomys natalensis). Longitudinal samples were collected during three months of bi-weekly trapping in Morogoro, Tanzania, and antibody titer and viral RNA presence were determined. The time of infection was estimated from these data using a recently developed Bayesian approach, which allowed us to assess whether the natural temporal patterns match the previously observed patterns in the laboratory. A good match was found for 52% of naturally infected individuals, while most of the mismatches can be explained by the presence of chronically infected individuals (35%), maternal antibodies (10%), and an antibody detection limit (25%). These results suggest that while laboratory data are useful for interpreting field samples, there can still be differences due to conditions that were not tested in the laboratory.en_US
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/4168
dc.language.isoenen_US
dc.publisherEcoHealth Allianceen_US
dc.subjectArenavirusen_US
dc.subjectMorogoro virusen_US
dc.subjectMastomys natalensisen_US
dc.subjectChallenge experimenten_US
dc.subjectMultimammate miceen_US
dc.subjectTime of infectionen_US
dc.titleArenavirus dynamics in experimentally and naturally infected rodentsen_US
dc.typeArticleen_US
dc.url10.1007/s10393-017-1256-7en_US

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