Brucellosis testing patterns at health facilities in Arusha region, northern Tanzania

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dc.contributor.authorLukambagire, AbdulHamid Settenda
dc.contributor.authorShirima, Gabriel Mkulima
dc.contributor.authorShayo, Damas Davis
dc.contributor.authorMathew, Coletha
dc.contributor.authorYapi, Richard B.
dc.contributor.authorKasanga, Christopher Julius
dc.contributor.authorMmbaga, Blandina Theophile
dc.contributor.authorKazwala, Rudovick Reuben
dc.contributor.authorHalliday, Jo E. B.
dc.date.accessioned2022-06-10T12:51:18Z
dc.date.available2022-06-10T12:51:18Z
dc.date.issued2022
dc.description.abstractBackground Brucellosis is listed as one of six priority zoonoses in Tanzania’s One Health strategic plan which highlights gaps in data needed for the surveillance and estimation of human brucello- sis burdens. This study collected data on current testing practices and test results for human brucellosis in Arusha region, northern Tanzania. Methods Retrospective data were extracted from records at 24 health facilities in Arusha region for the period January 2012 to May 2018. Data were captured on: the test reagents used for brucellosis, procurement and testing protocols, the monthly number of patients tested for brucellosis and the monthly number testing positive. Generalised linear mixed models were used to evaluate relationships between health facility characteristics and the probability that brucellosis testing was conducted in a given month, and the proportion of individuals testing positive. Results Four febrile Brucella agglutination tests were used widely. The probability of testing for bru- cellosis in a given month was significantly associated with an interaction between year of testing and facility ownership. Test probability increased over time with more pronounced increases in privately owned as compared to government facilities. The proportion of individ- uals testing positive for brucellosis was significantly associated with facility type and district, with individuals tested in hospitals in Meru, Monduli and Ngorongoro districts more likely to test positive. Conclusions Febrile Brucella agglutination tests, known for their poor performance, were the mainstay of brucellosis testing at health facilities in northern Tanzania. The study indicates that historical data on human brucellosis in Arusha and other regions are likely to provide an inaccurate measure of true disease burden due to poor performance of the tests used and variation in testing practices. Measures to address these identified shortcomings could greatly improve quality of testing and surveillance data on brucellosis and ultimately inform prevention and control of this priority disease.en_US
dc.identifier.citationLukambagire AS, Shirima GM, Shayo DD, Mathew C, Yapi RB, Kasanga CJ, et al. (2022) Brucellosis testing patterns at health facilities in Arusha region, northern Tanzania. PLoS ONE 17(3): e0265612. https://doi.org/10.1371/journal. pone.0265612en_US
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/4254
dc.language.isoenen_US
dc.publisherPLOS ONEen_US
dc.subjectBrucellosis testing patternsen_US
dc.subjectBrucellosisen_US
dc.subjectTesting patternsen_US
dc.subjectHealth facilitiesen_US
dc.subjectArusha regionen_US
dc.subjectNorthern Tanzaniaen_US
dc.titleBrucellosis testing patterns at health facilities in Arusha region, northern Tanzaniaen_US
dc.typeArticleen_US
dc.urlhttps://doi.org/10.1371/journal.pone.0265612en_US

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