Accuracy of giant African pouched rats for diagnosing tuberculosis: comparison with culture and Xpert W MTB/RIF
| dc.contributor.author | Mulder, C. | |
| dc.contributor.author | Mgode, G. F. | |
| dc.contributor.author | Ellis, H. | |
| dc.contributor.author | Valverde, E. | |
| dc.contributor.author | Beyene, N. | |
| dc.contributor.author | Cox, C. | |
| dc.contributor.author | Reid, S. E. | |
| dc.contributor.author | Van’t Hoog, A. H. | |
| dc.contributor.author | Edwards, T. L. | |
| dc.date.accessioned | 2020-06-02T11:26:38Z | |
| dc.date.available | 2020-06-02T11:26:38Z | |
| dc.date.issued | 2017 | |
| dc.description | The International Journal of Tuberculosis and Lung Disease 21(11):pg. 1127–1133 | en_US |
| dc.description.abstract | S E T T I N G : Enhanced tuberculosis (TB) case finding using detection rats in Tanzania. O B J E C T I V E S : To assess the diagnostic accuracy of detection rats compared with culture and Xpert w MTB/ RIF, and to compare enhanced case-finding algorithms using rats in smear-negative presumptive TB patients. D E S I G N : A fully paired diagnostic accuracy study in which sputum of new adult presumptive TB patients in Tanzania was tested using smear microscopy, 11 detection rats, culture and Xpert. R E S U LT S : Of 771 eligible participants, 345 (45%) were culture-positive for Mycobacterium tuberculosis, and 264 (34%) were human immunodeficiency virus (HIV) positive. The sensitivity of the detection rats was up to 75.1% (95%CI 70.1–79.5) when compared with cul- ture, and up to 81.8% (95%CI 76.0–86.5) when compared with Xpert, which was statistically signifi- cantly higher than the sensitivity of smear microscopy. Corresponding specificity was 40.6% (95%CI 35.9– 45.5) compared with culture. The accuracy of rat detection was independent of HIV status. Using rats for triage, followed by Xpert, would result in a statistically higher yield than rats followed by light- emitting diode fluorescence microscopy, whereas the number of false-positives would be significantly lower than when using Xpert alone. C O N C L U S I O N : Although detection rats did not meet the accuracy criteria as standalone diagnostic or triage testing for presumptive TB, they have additive value as a triage test for enhanced case finding among smear- negative TB patients if more advanced diagnostics are not available | en_US |
| dc.identifier.uri | https://www.suaire.sua.ac.tz/handle/123456789/3072 | |
| dc.language.iso | en | en_US |
| dc.publisher | Researchgate | en_US |
| dc.subject | Diagnostic | en_US |
| dc.subject | Olfactory detection | en_US |
| dc.subject | Criceto- mys ansorgei | en_US |
| dc.subject | Sensitivity | en_US |
| dc.subject | Specificity | en_US |
| dc.title | Accuracy of giant African pouched rats for diagnosing tuberculosis: comparison with culture and Xpert W MTB/RIF | en_US |
| dc.type | Article | en_US |
| dc.url | http://dx.doi.org/10.5588/ijtld.17.0139 | en_US |