Contagious bovine pleuropneumonia vaccines: the need for improvements

Simple item page
dc.contributor.authorRweyemamu, M.M
dc.contributor.authorLitamoi, J
dc.contributor.authorPalya, V
dc.contributor.authorSylla, D
dc.date.accessioned2022-06-08T11:40:38Z
dc.date.available2022-06-08T11:40:38Z
dc.date.issued2004-01
dc.description.abstractContagious bovine pleuropneumonia (CBPP) vaccines are routinely used only in Africa. The vaccines are usually produced from one of two strains (T1/44 and KH3J), each of which has a streptomycin-resistant variant. The necessity for a 'master seed strain' is evident. At least one manufacturer in Africa produces a broth culture vaccine, while others produce a freeze-dried product. A standardised manufacturing protocol needs to be developed, together with in-process and final product quality control procedures. Some CBPP vaccine manufacturing procedures do not allow sufficient leeway for the execution of typical quality control practices. For example, it is difficult to perform batch testing on broth culture vaccine, as the vaccine is produced in its final container. Quality control test results from the Pan African Veterinary Vaccine Centre (PANVAC) are analysed in terms of causes of batch failure and indicators for process development. Taking potency as an example, most vaccine batches tested by PANVAC pass only at the limit of the OIE minimum requirement of 107 colony-forming units per dose. To improve the titre of the vaccine, it will be necessary to modify the manufacturing process, either by increasing mycoplasma yield during the culture phase or by minimising losses during downstream processes, especially freeze-drying. Data on inactivated vaccines are scarce. Duration of the immunity achieved with live CBPP vaccines is relatively short, in comparison with other live vaccines. Data may be required on the molecular basis of virulence and immunogenicity, as well as on the molecular immunology of CBPP, to enable the development of improved vaccines.en_US
dc.identifier.issn0012-1606
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/4233
dc.language.isoenen_US
dc.subjectContagious bovine p l e u r o p n e u m o n i aen_US
dc.subjectMycoplasmaen_US
dc.subjectQuality controlen_US
dc.subjectVaccinesen_US
dc.titleContagious bovine pleuropneumonia vaccines: the need for improvementsen_US
dc.title.alternativethe need for improvementsen_US
dc.typeArticleen_US
dc.urlhttps://www.researchgate.net/publication/14607944en_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Contagiousbovinepleuropneumonia.PDF
Size:
611.39 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.67 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Articles, Conference and Workshop Papers Collection