Partial genetic characterization of peste des petits ruminants virus from goats in northern and eastern Tanzania

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dc.contributor.authorKgotlele, T.
dc.contributor.authorMacha, E. S.
dc.contributor.authorKasanga, C. J.
dc.contributor.authorKusiluka, L. J. M.
dc.contributor.authorKarimuribo, E. D.
dc.contributor.authorDoorsselaere, J. V.
dc.contributor.authorWensman, J. J.
dc.contributor.authorMunir, M.
dc.contributor.authorMisinzo, G.
dc.date.accessioned2017-06-23T16:41:18Z
dc.date.available2017-06-23T16:41:18Z
dc.date.issued2014
dc.descriptionTransboundary and Emerging Diseases 2014, Vol. 61(Suppl. 1): 56–62en_US
dc.description.abstractPeste des petits ruminants (PPR) is an acute viral disease of small ruminants. The disease was first reported in Tanzania in 2008 when it was confined to the Northern Zone districts bordering Kenya. The present study was carried out to confirm the presence of PPR virus (PPRV) in Tanzania and to establish their phylogenetic relationships. Samples (oculonasal swabs, tissues and whole blood) were obtained from live goats with clinical presentation suggestive of PPR and goats that died naturally in Ngorongoro (Northern Tanzania) and Mvomero (Eastern Tanzania) districts. The clinical signs observed in goats suspected with PPR included fever, dullness, diarrhea, lacrimation, matting of eye lids, purulent oculonasal discharges, cutaneous nodules, erosions on the soft palate and gums and labored breathing. Post mortem findings included pneumonia, congestion of the intestines, and hemorrhages in lymph nodes associated with the respiratory and gastrointestinal systems. PPRV was detected in 21 out of 71 tested animals using primers targeting the nucleoprotein (N) gene. Phylogenetic analysis, based on the N gene, indicated that PPRV obtained from Northern and Eastern Tanzania clustered with PPRV strains of Lineage III, together with PPRV from Sudan and Ethiopia. The findings of this study indicate that there are active PPRV infections in Northern and Eastern Tanzania, suggesting risks for potential spread of PPR in the rest of Tanzania.en_US
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/1681
dc.language.isoenen_US
dc.publisherTransboundary and Emerging Diseasesen_US
dc.subjectPeste des petits ruminantsen_US
dc.subjectRuminants virusen_US
dc.subjectPhylogenyen_US
dc.subjectNucleoprotein geneen_US
dc.titlePartial genetic characterization of peste des petits ruminants virus from goats in northern and eastern Tanzaniaen_US
dc.typeArticleen_US

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