First Report on a Randomized Investigation of Antimicrobial Resistance in Fecal Indicator Bacteria from Livestock, Poultry, and Humans in Tanzania

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dc.contributor.authorKatakweba, Abdul A. S.
dc.contributor.authorMuhairwa, Amandus P.
dc.contributor.authorLupindu, Athumani M.
dc.contributor.authorDamborg, Peter
dc.contributor.authorRosenkrantz, Jesper T.
dc.contributor.authorMinga, Uswege M.
dc.contributor.authorMtambo, Madundo M. A.
dc.contributor.authorOlsen, John E.
dc.date.accessioned2018-06-13T11:29:06Z
dc.date.available2018-06-13T11:29:06Z
dc.date.issued2018-04-01
dc.descriptionJournal articleen_US
dc.description.abstractThis study provides an estimate of antimicrobial resistance in intestinal indicator bacteria from humans (n = 97) and food animals (n = 388) in Tanzania. More than 70% of all fecal samples contained tetracycline (TE), sulfamethoxazole (STX), and ampicillin (AMP)-resistant coliforms, while cefotaxime (CTX)-resistant coliforms were observed in 40% of all samples. The average Log10 colony forming units/g of CTX-resistant coliforms in samples from humans were 2.20. Of 390 Escherichia coli tested, 66.4% were resistant to TE, 54.9% to STX, 54.9% to streptomycin, and 36.4% to CTX. Isolates were commonly (65.1%) multiresistant. All CTX-resistant isolates contained blaCTX-M gene type. AMP- and vancomycin-resistant enterococci were rare, and the average concentrations in positive samples were low (log10 0.9 and 0.4, respectively). A low-tomoderate resistance (2.1–15%) was detected in 240 enterococci isolates to the drugs tested, except for rifampicin resistance (75.2% of isolates). The average number of sulII gene copies varied between Log10 5.37 and 5.68 with no significant difference between sample source, while cattle had significantly higher number of tetW genes than humans. These findings, based on randomly obtained samples, will be instrumental in designing antimicrobial resistance (AMR) intervention strategies for Tanzania.en_US
dc.identifier.otherhttps://doi.org/10.1089/mdr.2016.0297
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/2333
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.subjectfecal indicator bacteria, antimicrobial resistance, blactx-M, Tanzaniaen_US
dc.titleFirst Report on a Randomized Investigation of Antimicrobial Resistance in Fecal Indicator Bacteria from Livestock, Poultry, and Humans in Tanzaniaen_US
dc.typeArticleen_US
dc.urlhttps://doi.org/10.1089/mdr.2016.0297en_US

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