Dose-response relationships in a microneutralization test for foot-and-mouth disease viruses

dc.contributor.author	Booth, J. C
dc.contributor.author	Rweyemamu, M. M
dc.contributor.author	Pay, T. W. F
dc.date.accessioned	2022-05-06T11:09:41Z
dc.date.available	2022-05-06T11:09:41Z
dc.date.issued	1977-05
dc.description.abstract	Two-dimensional quantal microneutralization tests on foot-and-mouth disease viruses, in which neutralizing antibody activity was titrated against a serial range of virus doses, demonstrated a variety of dose-response curves some of which were rectilinear, others clearly curvilinear. Moreover, in the case of the non-linear responses obtained with some antisera, the shape of the curve was such that antibody titres recorded with doses of virus ranging from lCP-lO 5 TCD50 were closely similar. Studies were carried out on the effect of varying the con- ditions of the test on the shape of the dose-response curve: significant differences were obtained after treatment of the antiserum-virus mixtures with anti-species globulin, and when the test was assayed in cells of differing susceptibility to infection.	en_US
dc.identifier.uri	https://www.suaire.sua.ac.tz/handle/123456789/4056
dc.language.iso	en	en_US
dc.subject	Microneutralization test	en_US
dc.subject	Antiglobulin serum	en_US
dc.subject	Foot-mouth disease viruses	en_US
dc.title	Dose-response relationships in a microneutralization test for foot-and-mouth disease viruses	en_US
dc.type	Article	en_US
dc.url	https://www.cambridge.org/core	en_US

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