Association of long-term pesticide exposure and biologic parameters in female farm workers in Tanzania: A cross sectional study

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dc.contributor.authorManyilizu, W. B.
dc.contributor.authorMdegela, R. H.
dc.contributor.authorKazwala, R. R.
dc.contributor.authorNonga, H. E.
dc.contributor.authorMüller, M. B.
dc.contributor.authorLie, E.
dc.contributor.authorSkjerve, E.
dc.contributor.authorLyche, J. L.
dc.date.accessioned2018-07-19T13:34:24Z
dc.date.available2018-07-19T13:34:24Z
dc.date.issued2016-09-29
dc.description.abstractThe study aimed to assess the association of long-term pesticide exposure (5 years) with hematological, serum biochemical parameters and acetylcholinesterase activity in farm workers. These pesticides included organophosphorus pesticides, carbamates, pyrethroids, dithiocarbamates, and other pesticides such as endosulfan. Applying a cross-sectional study design, 69 females from a pesticide-exposed farm population and 30 females from a district not using pesticides (reference group) were studied. The mean red cell corpuscular volume and hematocrit values were significantly lower (74.7 9.1 fl; 95% CI 72.5–76.9 and 32.0% 4.6%; 95% CI 30.9–33.1, respectively) in the exposed compared to the reference group, whereas mean corpuscular hemoglobin concentration and platelets were significantly higher (37.4 3.8 g/dL; 95% CI 36.5–38.3 and 374.1 95.3/L; 95% CI 351.2–396.9, respectively) in the exposed compared to the reference group. Mean serum glutamic oxaloacetate transaminase (20.7 8.9 U/L; 95% CI 18.5–22.9) and creatinine (83.9 6.6 mol/L; 95% CI 82.3–85.5) were significantly higher in the exposed compared to the reference group. A higher mean esterase activity (AChE 0.6 0.2 mM/min/mg protein; 95% CI 0.56–0.7; BChE 0.9 0.4 mM/min/mg protein; 95% CI 0.9–1.1) was noted in the exposed group. Regression models suggest that occupational exposure (p < 0.001) could be a predictor of esterase (AChE and BChE) activity and biochemical changes (= 0.4, 95% CI: 0.3–0.5; = 0.7, 95% CI: 0.6–0.9, respectively). Long-term pesticide exposure affects the hemato-biochemical and esterase responses, establishing the need for further studies.en_US
dc.description.sponsorshipResearch Council of Norway (NFR nr: 204051)en_US
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/2559
dc.language.isoenen_US
dc.publisherToxicsen_US
dc.subjectPesticidesen_US
dc.subjectHematologicalen_US
dc.subjectBiochemicalen_US
dc.subjectAcetylcholine esterase activityen_US
dc.subjectEffectsen_US
dc.titleAssociation of long-term pesticide exposure and biologic parameters in female farm workers in Tanzania: A cross sectional studyen_US
dc.typeArticleen_US
dc.urlhttps://www.ncbi.nlm.nih.gov/pubmed/29051428en_US

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