Sokoine University of Agriculture

Prevalence of plasmodium infection and accuracy of diagnostic tests for malaria infection in children under five in the health zone of Mont Ngafula1, an endemic area for malaria in Kinshasa, DRC

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dc.contributor.author Tevuzula, Vivi Maketa
dc.date.accessioned 2015-10-01T13:51:31Z
dc.date.available 2015-10-01T13:51:31Z
dc.date.issued 2014
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/644
dc.description Masters Dissertation en_US
dc.description.abstract Democratic Republic of Congo (DRC) is one of the five countries that carry half of the global disease burden. Yet, malaria is an entirely preventable and treatable disease, when currently recommended interventions are properly implemented. Such interventions include confirmation of malaria diagnosis through microscopy or malaria rapid diagnostic tests (MRDTs) for every suspected case, even in children under five years of age. This study aimed to assess the prevalence of malaria infection and the performances of MRDT, the SD-Bioline a HRP2/PanLDH test using microscopy and PCR as the gold standard in a population based survey in children under five years of age living in endemic transmission settings. This is a cross sectional based survey conducted in the health areas in the health zone of Mont Ngafula1 during the dry season from April to August 2012. A total of 812 children of 3 to 59 months of age were included from the 2 selected HA. The sensitivity, specificity, positive and negative predictive values with their CI 95% were 93.5% (90.0-97.1), 81.1% (77.9-84.2), 60.6% (55.0-66.3) and 97.5% (96.2-98.9), respectively, in the overall study population when using microscopy as the gold standard and 88%.2 (79.2-97.3), 92.0% (84.3-99.7), 88.4% (79.6-97.3) and 91.8% (84.0-99.7) respectively, when PCR was used as the reference test . The prevalence of malaria with microscopy was 24.9% (CI 95%: 21.0-26.7).The differences between PCR and microscopy with the specificity or and the PPV in the overall population might be due to the threshold detection of microscopy that does not detect very low parasite density. The results of this study show the limitation of the MRDT SD-Bioline, a HRP2/PanLDH test, on population based survey because of the risk of an overestimation of the infection prevalence in children aged less than five years. en_US
dc.description.sponsorship Southern African Centre for Infectious Disease Surveillance (SACIDS) en_US
dc.language.iso en en_US
dc.language.iso en en_US
dc.language.iso en en_US
dc.language.iso en en_US
dc.publisher Sokoine University of Agriculture en_US
dc.subject Prevalence plasmodium en_US
dc.subject Malaria diagnosis en_US
dc.subject Malaria infection en_US
dc.subject Malaria en_US
dc.subject Mont Ngafula1 en_US
dc.subject Kinshasa Democratic Republic of Congo (DRC) en_US
dc.title Prevalence of plasmodium infection and accuracy of diagnostic tests for malaria infection in children under five in the health zone of Mont Ngafula1, an endemic area for malaria in Kinshasa, DRC en_US
dc.type Thesis en_US
dc.type Thesis en_US
dc.type Thesis en_US
dc.type Thesis en_US


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