Sokoine University of Agriculture

Prevalence of Asymptomatic and Submicroscopic Malaria Parasitaemia in korogwe, North-Eastern Tanzania

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dc.contributor.author Martine, P.
dc.date.accessioned 2021-02-17T12:52:44Z
dc.date.available 2021-02-17T12:52:44Z
dc.date.issued 2019
dc.identifier.uri https://www.suaire.sua.ac.tz/handle/123456789/3389
dc.description M.Sc. Dissertation en_US
dc.description.abstract Despite the intensification in malaria control interventions, malaria still remains a major public health problem in malaria endemic settings. Asymptomatic infections that largely remain undetected act as reservoir of transmission jeopardizing the current control efforts. The aim of this study was to determine the prevalence of asymptomatic malaria infection, anaemia and submicroscopic parasitaemia in individuals of Korogwe District, a malaria endemic setting in north-eastern Tanzania. A community-wide cross-sectional malariometric survey involving participants aged 0-19 years was conducted in two villages of Korogwe District, a malaria endemic setting in north-eastern Tanzania. Parasite DNA was extracted from dried blood spots (DBS) collected during the survey. Detection of submicroscopic malaria infection from slide negative cases was done by Plasmodium genus and species- specific nucleotide amplification method. Out of 565 participants, 211 (37.41%, 95% CI: 33.99-41.49%) had malaria infection after testing using malaria rapid diagnostic test (mRDT), whereas only 81 (14.38%, 95% CI: 11.71-17.54%) were malaria positive by microscopy. Of the 565 participants, 130 (23.0%, 95% CI: 19.71-26.67%) and 33 (5.84%, 95% CI: 4.18-8.11%) had asymptomatic malaria based on mRDT and microscopy, respectively. Out of 565 participants, 135 (23.89%, 95% CI: 20.54-27.59%) were anaemic. Three out of 206 (1.5%, 95% CI: 0.47-4.46%) samples that were malaria negative by microscopy were found to be positive when analyzed by polymerase chain reaction (PCR), indicating the presence of submicroscopic malaria. Multivariate logistic regression analysis for predictors of anaemia showed that, participants aged between 5-9 and 10-14 years were significantly associated with asymptomatic malaria and anaemia (adjusted odds ratio (AOR) = 0.6, 95% CI: 0.37-0.98, p = 0.04) and (AOR = 0.32, 95% CI: 0.14-0.75, p = 0.01), respectively. The current study observed that asymptomatic malaria is much more prevalent in participants aged above five years. Furthermore, participants aged 5-14 years were at risk of asymptomatic malaria associated with anaemia. A low proportion of submicroscopic parasitaemia was observed in this study. The findings highlight the need for targeted interventions focusing on those participants aged above five years in malaria control interventions. en_US
dc.language.iso en en_US
dc.publisher Sokoine University of Agriculture en_US
dc.subject Submicroscopic en_US
dc.subject Malaria en_US
dc.subject Parasitaemia en_US
dc.subject Korogwe en_US
dc.subject North-Eastern en_US
dc.subject Tanzania en_US
dc.subject Asymptomatic malaria infection en_US
dc.title Prevalence of Asymptomatic and Submicroscopic Malaria Parasitaemia in korogwe, North-Eastern Tanzania en_US
dc.type Thesis en_US


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