Sokoine University of Agriculture

Rapid molecular evolution of pain insensitivity in multiple African rodents

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dc.contributor.author Eigenbrod, O.
dc.contributor.author Debus, K. Y.
dc.contributor.author Reznick, J.
dc.contributor.author Bennett, N. C.
dc.contributor.author Sánchez-Carranza, O.
dc.contributor.author Omerbašić, D.
dc.contributor.author Hart, D. W.
dc.contributor.author Barker, A. J.
dc.contributor.author Zhong, W.
dc.contributor.author Lutermann, H.
dc.contributor.author Katandukila, J. V.
dc.contributor.author Mgode, G.
dc.contributor.author Park, T. J.
dc.contributor.author Lewin, G. R.
dc.date.accessioned 2020-06-08T15:10:21Z
dc.date.available 2020-06-08T15:10:21Z
dc.date.issued 2019-05-31
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/3081
dc.description Research Article of Science 364, pg. 852–859 (2019) en_US
dc.description.abstract Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Na v 1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors. These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant. Our study reveals how evolution can be used as a discovery tool to find molecular mechanisms that shut down pain. en_US
dc.language.iso en en_US
dc.publisher Science sciencemag en_US
dc.subject Rapid molecular evolution en_US
dc.subject Pain insensitivity en_US
dc.subject Multiple African rodents en_US
dc.title Rapid molecular evolution of pain insensitivity in multiple African rodents en_US
dc.type Article en_US
dc.url https://science.sciencemag.org/content/364/6443/852 en_US


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