Sokoine University of Agriculture

Pediatric tuberculosis detection using trained African giant pouched rats

Show simple item record Mgode, G. F. Cox, C. L. Mwimanzi, S. Mulder, C. 2020-06-05T08:15:55Z 2020-06-05T08:15:55Z 2018
dc.description Article of Basic Science Volume 84 | Number 1 | July 2018, pg. 99-103 en_US
dc.description.abstract BACKGROUND: Tuberculosis (TB) diagnosis in children is a challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Therefore, new diagnostic tests are needed for TB diagnosis. We determined the performance of trained rats in the diagnosis of pediatric TB and whether they can improve detection rate compared to the standard of care. METHODS: Presumptive TB patients in 24 TB clinics in Tanzania were tested. Samples indicated as TB-positive by rats underwent confirmation by concentrated smear microscopy. TB yield of bacteriologically confirmed pediatric TB patients (≤5 years) was compared with yield of standard of care. RESULTS: Sputum samples from 55,148 presumptive TB patients were tested. Nine hundred eighty-two (1.8%) were the children between 1 and 5 years. Clinics detected 34 bacteriologically positive children, whereas rats detected additional 23 children yielding 57 bacteriologically TB- positive children. Rats increased pediatric TB detection by 67.6%. Among 1–14-year-old children, clinics detected 331 bacteriologically positive TB whereas rats found the additional 208 children with TB that were missed by clinics. Relative increase in TB case detection by rats decreased with the increase in age (Po0.0001). CONCLUSION: Trained rats increase pediatric TB detection significantly and could help address the pediatric TB diagnosis challenges. Further determination of accuracy of rats involving other sample types is still needed. en_US
dc.language.iso en en_US
dc.publisher 2018 International Pediatric Research Foundation, Inc. en_US
dc.subject Pediatric tuberculosis detection en_US
dc.subject Trained African Giant en_US
dc.subject Pouched rats en_US
dc.subject Tuberculosis (TB) diagnosis en_US
dc.title Pediatric tuberculosis detection using trained African giant pouched rats en_US
dc.type Article en_US
dc.url doi:10.1038/pr.2018.40 en_US

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