Sokoine University of Agriculture

Anti-Mycobacterial Activity on Middlebrook 7H10 Agar of Selected Congolese Medicinal Plants

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dc.contributor.author Bongo, G.N
dc.contributor.author Tuntufye, H.N
dc.contributor.author Malakalinga, J
dc.contributor.author Ngbolua, K
dc.contributor.author Pambu, A.L
dc.contributor.author Claudine, T
dc.contributor.author Mbadiko, C.M
dc.contributor.author Kazwa, R
dc.date.accessioned 2019-10-29T05:35:23Z
dc.date.available 2019-10-29T05:35:23Z
dc.date.issued 2018-12-06
dc.identifier.issn 2381-7690 (Print)
dc.identifier.issn 2381-7704 (Online)
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/2932
dc.description Bioscience and Bioengineering' 2018; 4 (4): 68-77 en_US
dc.description.abstract In recent years, Tuberculosis (TB) has re-emerged as a serious public health problem worldwide. The disease spreads more easily in overcrowded settings and in conditions of malnutrition and poverty. The emergence of multidrug resistant and lengthy therapy reduces the patient compliance which comprises TB control strategies. In the current study, the leaves of Terminalia ivorensis, Carapa procera, Fagara macrophylla, Anacardium occidentale, Ficus spp. and Drepanoalpha® were extracted using petroleum ether, ethyl acetate and methanol in order to assess their anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium tuberculosis spp. on Middlebrook 7H10 agar using a qualitative approach where the activity was determined by the presence or the absence of growth on the plate. The phytochemical screening was used for the identification of the major groups of compounds found in the extracts. The methanolic extract displayed a good activity on both strains than the petroleum ether and ethyl acetate. The presence of alkaloids, flavonoids, tannins, saponins, anthocyanins, quinones known to be of medicinal importance points out a possible source for anti-mycobacterial agents to address the problem of multidrug resistance. The in vitro findings of this study provide a partial support for the use of these plants in the management of various infectious diseases as lead to drug discovery and should be reiterated and recommended for a clinical trial using an animal model. en_US
dc.description.sponsorship BEBUC Scholarship System, (Bourse d’Excellence Bringmann aux Universites Congolaises), the Else-Kroener-Fresenius Stiftung, the Holger-Pohlmann-Foundation (Deutschland) and INTRA ACP Academic Mobility Scheme en_US
dc.language.iso en en_US
dc.publisher American Institute of Science en_US
dc.relation.ispartofseries Bioscience and Bioengineering;4
dc.subject Tuberculosis en_US
dc.subject Middlebrook 7H10 Agar en_US
dc.subject Anti-mycobacterial Activity en_US
dc.subject Phytochemical Screening en_US
dc.subject Medicinal Plants en_US
dc.title Anti-Mycobacterial Activity on Middlebrook 7H10 Agar of Selected Congolese Medicinal Plants en_US
dc.type Article en_US
dc.url http://creativecommons.org/licenses/by/4.0/ en_US


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