Sokoine University of Agriculture

Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration

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dc.contributor.author Matondo, RB
dc.contributor.author Punt, C
dc.contributor.author Homberg, J
dc.contributor.author Toussaint, MJM
dc.contributor.author Kisjes, R
dc.contributor.author Korporaal, SJA
dc.contributor.author Akkerman, JWN
dc.contributor.author Cuppen, E
dc.contributor.author de Bruin, A
dc.date.accessioned 2018-10-09T08:19:32Z
dc.date.available 2018-10-09T08:19:32Z
dc.date.issued 2009-04-01
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/2619
dc.description.abstract The serotonin transporter is implicated in the uptake of the vasoconstrictor serotonin from the circulation into the platelets, where 95% of all blood serotonin is stored and released in response to vascular injury. In vivo studies indicated that platelet-derived serotonin mediates liver regeneration after partial hepatectomy. We have recently generated serotonin transporter knockout rats and demonstrated that their platelets were almost completely depleted of serotonin. Here we show that these rats exhibit impaired hemostasis and contain about 1–6% of wild-type serotonin levels in the blood. Despite the marked reduction of serotonin levels in blood and platelets, efficient liver regeneration and collagen-induced platelet aggregation occur in rats lacking the serotonin transporter. These results provide evidence that liver regeneration is not dependent on the release of serotonin from platelets. Our findings indicate that very low levels of serotonin in blood are sufficient for liver regeneration. en_US
dc.language.iso en en_US
dc.publisher American Physiological Society en_US
dc.subject Serotonin en_US
dc.subject liver en_US
dc.subject regeneration en_US
dc.subject transporter en_US
dc.subject Rat en_US
dc.title Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration en_US
dc.type Article en_US
dc.url https://www.physiology.org/doi/full/10.1152/ajpgi.90709.2008 en_US


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