Sokoine University of Agriculture

Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human breast milk and associated health risks to nursing infants in northern Tanzania

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dc.contributor.author Müller, M. B.
dc.contributor.author Polder, A.
dc.contributor.author Brynildsrud, O. B.
dc.contributor.author Karimi, M.
dc.contributor.author Lie, E.
dc.contributor.author Manyilizu, W. B.
dc.contributor.author Mdegela, R. H.
dc.contributor.author Mokiti, F.
dc.contributor.author Murtadha, M.
dc.contributor.author Nonga, H. E.
dc.contributor.author Skaare, J. U.
dc.contributor.author Lyche, J. L.
dc.date.accessioned 2018-07-18T16:27:59Z
dc.date.available 2018-07-18T16:27:59Z
dc.date.issued 2017-01-25
dc.identifier.issn 0013-9351
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/2552
dc.description.abstract This is the first study to report organochlorines (OCs), including chlorinated pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human milk from Tanzania. The main aims of this study were to assess the level of contamination and the possible health risks related to OC exposure in nursing infants from the Northern parts of Tanzania. Ninety-five healthy mother-infant couples attending Mount Meru Regional Referral Hospital (MMRRH), Arusha, Tanzania, were assessed for associations between maternal/infant characteristics, i.e. mother's age, BMI, gestational weight gain, occupation, residence and fetal growth parameters and breast milk levels of OCPs, such as dichlorodiphenyltrichloroethane (DDT) and its metabolites, dieldrin and PCBs. p,p′-DDE and p,p′-DDT were detected in 100% and 75% of the breast milk samples, respectively, and ranged between 24 and 2400 ng/g lipid weight (lw) and < LOD and 133 ng/g lw, respectively. Dieldrin was detected in 66% of the samples in levels up to 937 ng/g lw. Σ7PCBs ranged between < LOD and 157 ng/g lw. Other OCPs were detected in low levels. For assessment of health risks, the Hazard Quotient (HQ) was calculated by comparing estimated daily intakes of OCPs and PCBs with health based guidance values. The estimated daily intake (ng/kg body weight/day) of ΣDDTs, dieldrin and nondioxin-like PCBs (Σ6PCBs) exceeded the provisional tolerable daily intake (PTDI) in two, six and forty-eight of the nursing infants, respectively, suggesting potential health risks. In addition, head circumference were negatively associated with p,p´-DDE in female infants, suggesting that OC exposure during pregnancy may influence fetal growth. en_US
dc.description.sponsorship Research Council of Norway (NFR nr: 204051). en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Organochlorine pesticides en_US
dc.subject Polychlorinated biphenyls en_US
dc.subject Human breast milk en_US
dc.subject Estimated daily intake en_US
dc.subject Infant health risks en_US
dc.title Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human breast milk and associated health risks to nursing infants in northern Tanzania en_US
dc.type Article en_US
dc.url https://www.ncbi.nlm.nih.gov/pubmed/28196346 en_US


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