Sokoine University of Agriculture

Contribution of microbiota to innate and acquired gut immunity during health and disease

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dc.contributor.author Malago, J. J.
dc.date.accessioned 2018-06-17T10:00:58Z
dc.date.available 2018-06-17T10:00:58Z
dc.date.issued 2014
dc.identifier.isbn 978-1-63117-296-0
dc.identifier.uri https://www.suaire.sua.ac.tz/handle/123456789/2365
dc.description Book en_US
dc.description.abstract The contribution of intestinal epithelium to the innate immune system includes detecting luminal microbes, transducing signals, and activating inflammatory mediator release by epithelial and other cells of the immune system like the antigen presenting cells. Microbial antigens are detected by cells of the innate immune system through their pattern recognition receptors (PRRs). The PRRs recognize microbe-associated molecular patterns and generate signals that activate transcription pathways like nuclear factor kappa B and mitogen activated protein kinases. This activation leads to production of inflammatory and growth mediators that drive the immune system to elicit tolerance or immune response designated at maintaining immune homeostasis. Key to this signaling is the gut microbiota. Intestinal epithelial cell sensing of optimally balanced microbiota favors immune homeostasis whereas sensing under disrupted microbiota impairs immune function and predisposes to disease. Understanding the PRR-microbiota signaling would be useful in designing therapeutics for various immune-mediated disorders caused by imbalances of microbiota. en_US
dc.language.iso en en_US
dc.publisher Nova Science Publishers, Inc en_US
dc.subject Immune system en_US
dc.subject Microbiota pattern en_US
dc.subject Intestinal immunity en_US
dc.subject Immune homeostasis en_US
dc.title Contribution of microbiota to innate and acquired gut immunity during health and disease en_US
dc.title.alternative Influence of microbiota to pattern recognition receptor signaling for intestinal immunity en_US
dc.type Book en_US
dc.url http://www.novapublishers.com en_US


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