Sokoine University of Agriculture

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge

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dc.contributor.author Lankester, F.
dc.contributor.author Lugelo, A.
dc.contributor.author Werling, D.
dc.contributor.author Mnyambwa, N.
dc.contributor.author Keyyu, J.
dc.contributor.author Kazwala, R.
dc.contributor.author Grant, D.
dc.contributor.author Smith, S.
dc.contributor.author Parameswaran, N.
dc.contributor.author Cleaveland, S.
dc.contributor.author Russell, G.
dc.contributor.author Haig, D.
dc.date.accessioned 2017-12-19T09:28:46Z
dc.date.available 2017-12-19T09:28:46Z
dc.date.issued 2016-11-15
dc.identifier.issn 144-153
dc.identifier.uri https://www.suaire.sua.ac.tz/handle/123456789/1939
dc.description Journal Veterinary microbiology Volume 195 Pages 144-153 en_US
dc.description.abstract Malignant catarrhal fever (MCF) is a fatal disease of cattle that, in East Africa, follows contact with wildebeest excreting alcelaphine herpesvirus 1 (AlHV-1). Recently an attenuated vaccine (atAlHV-1) was tested under experimental challenge on Friesian-Holstein (FH) cattle and gave a vaccine efficacy (VE) of approximately 90%. However testing under field conditions on an East African breed, the shorthorn zebu cross (SZC), gave a VE of 56% suggesting that FH and SZC cattle may respond differently to the vaccine. To investigate, a challenge trial was carried out using SZC. Additionally three adjuvant combinations were tested: (i) Emulsigen®, (ii) bacterial flagellin (FliC) and (iii) Emulsigen® + bacterial flagellin. We report 100% seroconversion in all immunized cattle. The group inoculated with atAlHV-1 + Emulsigen® had significantly higher antibody titres than groups inoculated with FliC, the smallest number of animals that became infected and the fewest fatalities, suggesting this was the most effective combination. A larger study is required to more accurately determine the protective effect of this regime in SZC. There was an apparent inhibition of the antibody response in cattle inoculated with atAlHV-1 + FliC, suggesting FliC might induce an immune suppressive mechanism. The VE in SZC (50 – 60%) was less than that in FH (80 – 90%). We speculate that this might be due to increased risk of disease in vaccinated SZC (suggesting that the vaccine may be less effective at stimulating an appropriate immune response in this breed) and/or increased survival in unvaccinated SZC (suggesting that these cattle may have a degree of prior immunity against infection with AlHV-1). en_US
dc.language.iso en en_US
dc.publisher Veterinary Microbiology en_US
dc.subject Malignant catarrhal fever en_US
dc.subject Alcelaphine herpesvirus en_US
dc.subject Vaccine trial en_US
dc.subject Wildebeest en_US
dc.subject Adjuvant en_US
dc.subject Bacterial flagellin en_US
dc.title The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge en_US
dc.type Article en_US
dc.url http://www.sciencedirect.com/science/article/pii/S037811351630387X en_US


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