Sokoine University of Agriculture

When viruses don’t go viral: the importance of host phylogeographic structure in the spatial spread of arenaviruses

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dc.contributor.author Gryseels, S.
dc.contributor.author Baird, S. J. E.
dc.contributor.author Borremans, B.
dc.contributor.author Makundi, R.
dc.contributor.author Leirs, H.
dc.contributor.author Bellocq, J. G.
dc.date.accessioned 2017-12-12T05:53:15Z
dc.date.available 2017-12-12T05:53:15Z
dc.date.issued 2017
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/1873
dc.description Journal PLoS pathogens, 2017; 13 (1) en_US
dc.description.abstract Many emerging infections are RNA virus spillovers from animal reservoirs. Reservoir identification is necessary for predicting the geographic extent of infection risk, but rarely are taxonomic levels below the animal species considered as reservoir, and only key circumstances in nature and methodology allow intrinsic virus-host associations to be distinguished from simple geographic (co-)isolation. We sampled and genetically characterized in detail a contact zone of two subtaxa of the rodent Mastomys natalensis in Tanzania. We find two distinct arenaviruses, Gairo and Morogoro virus, each spatially confined to a single M. natalensis subtaxon, only co-occurring at the contact zone’s centre. Inter-subtaxon hybridization at this centre and a continuum of quality habitat for M. natalensis show that both viruses have the ecological opportunity to spread into the other substaxon’s range, but do not, strongly suggesting host-intrinsic barriers. Such barriers could explain why human cases of another M. natalensisborne arenavirus, Lassa virus, are limited to West Africa en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.subject Viral viruses en_US
dc.subject Phylogeographic structure en_US
dc.subject RNA virus spillovers en_US
dc.subject Animal reservoirs en_US
dc.subject Intrinsic virus-host association en_US
dc.title When viruses don’t go viral: the importance of host phylogeographic structure in the spatial spread of arenaviruses en_US
dc.type Article en_US
dc.url http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006073 en_US


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