Sokoine University of Agriculture

Clinical implication of novel drug resistance-conferring mutations in resistant tuberculosis

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dc.contributor.author Mnyambwa, N. P.
dc.contributor.author Kim, J.
dc.contributor.author Ngadaya, E. S.
dc.contributor.author Kazwala, R.
dc.contributor.author Petrucka, P.
dc.contributor.author Mfinanga, S. G.
dc.date.accessioned 2017-12-11T06:01:08Z
dc.date.available 2017-12-11T06:01:08Z
dc.date.issued 2017
dc.identifier.uri http://www.suaire.sua.ac.tz/handle/123456789/1864
dc.description.abstract Evolving novel and/or unfamiliar mutations are revolutionizing the pathways of antibiotic resistance of clinical tuberculosis. The accumulation and interaction of these poorly characterized mutations augment the complexity of resistant pathogenic strains and raise public health concerns. This article reviews our current understanding of the genetic changes that characterize drug resistance in tuberculosis and highlights the imperative for further investigations focusing on the effects of an individual mutation and interacting mutations with detailed strain epidemiology, particularly as these pertain to technologylimited countries with high tuberculosis incidence rates. Concomitantly, there is a need for the development, testing, and uptake of new tools for studying the effects of these mutations in drug resistance and fitness cost of the pathogen. Such genetic data are critical for effective localized and global tuberculosis control interventions and for accurate epidemiological predictions. en_US
dc.language.iso en en_US
dc.publisher Springer Berlin Heidelberg en_US
dc.subject Clinical implication en_US
dc.subject Novel drug resistance en_US
dc.subject Resistant tuberculosis en_US
dc.title Clinical implication of novel drug resistance-conferring mutations in resistant tuberculosis en_US
dc.type Article en_US
dc.url https://link.springer.com/article/10.1007/s10096-017-3027-3 en_US


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