Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of General Virology
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) emerged in the late 1980s and
rapidly became one of the most significant viral pathogens in the swine industry. In vivo, the virus
shows a very narrow cell tropism and targets specific subsets of porcine macrophages. The entry
of PRRSV into its host cell is the first crucial step in infection and has been the focus of many
fundamental studies. This review provides a comprehensive overview of the current knowledge on
PRRSV entry into the porcine macrophage, covering virus binding, internalization and genome
release, and integrates these findings into a general model of the entry process.
Description
Journal of General Virology 2010, Vol. 91: 1659–1667
Keywords
Syndrome virus, Porcine macrophage, Porcine reproductive, PRRSV, Arteriviridae, Nidovirales